

If you are a founder, marketer, or agency lead, your week probably starts inside a spreadsheet. You are cleaning CRM exports, stitching ad data to revenue, and wrestling with columns that never quite line up. Selecting multiple columns sounds trivial until you are doing it across dozens of tabs and files, on desktop and mobile, with different keyboard quirks in Google Sheets and Excel.In Sheets, you drag headers for adjacent columns, use Ctrl or Cmd for non-adjacent ones, and Shift for ranges. On some Macs, a stray browser plugin even blocks command-click selection, forcing you into tedious workarounds. In Excel, the patterns are similar, but muscle memory does not always transfer. Multiply those tiny frictions by the number of reports your team touches and you have a hidden tax on every campaign.This is exactly where an AI computer agent becomes strategic. Instead of you remembering every shortcut, the agent can learn your exact selection patterns, repeat them flawlessly across files, and chain them into larger workflows like VLOOKUP setups or ARRAYFORMULA expansions. You stop burning attention on mechanics, and start using Sheets and Excel as decision engines rather than click playgrounds.
Every serious business eventually runs on spreadsheets. A sales leader exporting CRM data, a marketer joining ad spend to revenue, an agency building weekly client reports – all of them live in Google Sheets and Excel. And almost all of them waste time just selecting the right columns before they can do anything useful.This guide walks through three layers of mastery: manual techniques, no-code automation, and finally AI agents that can operate Sheets and Excel for you at scale.### 1. Manual methods in Google Sheets and ExcelThese are the foundations your AI agent will later mimic.1) Select a single column- Google Sheets: Click the column letter at the top (for example, C). The whole column highlights.- Excel: Same pattern – click the column header letter.2) Select multiple adjacent columns (side-by-side)- Click the first column header (for example, B).- Hold and drag your mouse across to the last column (for example, F).- Release – in both Google Sheets and Excel, B through F are now selected.This is perfect for formatting, adding filters, or deleting several columns at once.3) Select a continuous range with Shift- Click the first column header.- Hold Shift.- Click the last column header in the range.- Sheets and Excel both select everything from the first to the last column. This is faster and more precise than click-drag when you have wide sheets.4) Select non-adjacent columns with Ctrl or Cmd- Click the first column you want.- Hold Ctrl (Windows) or Cmd (Mac).- Click additional column headers anywhere in the sheet.- Each clicked column stays highlighted.If Ctrl/Cmd-click does not work in Google Sheets on Mac, test in an incognito window – as some Apple Community users found, a browser plugin can silently block this behavior.5) Select all columns at once- In Google Sheets: Click the blank rectangle at the top-left corner, where the row numbers and column letters meet.- In Excel: Same top-left corner box.This selects the entire grid – useful before bulk formatting or clearing.6) Mobile selection in Google SheetsOn phones and tablets the gestures differ and are more limited.- Tap a column letter to select a single column.- Long-press, then drag selection handles to expand.- Multi-column selection is more constrained than on desktop; refer to the official Google Docs Editors Help Center for device-specific options: https://support.google.com/docs/For heavy column work, desktop will always be faster and easier.7) Keyboard shortcutsIn Google Sheets (desktop):- Ctrl + Space (Cmd + Space on Mac) selects the current column when your cursor is in any cell of that column.- Combine this with Shift + Arrow keys to extend the selection.See Google Sheets keyboard shortcuts: https://support.google.com/docs/In Excel (Windows and Mac):- Ctrl + Space selects the entire column.- Ctrl + Shift + Arrow keys extend the selection across multiple columns.See Excel keyboard shortcuts via Microsoft support: https://support.microsoft.com/excelThese manual moves are your baseline. They also define the behaviors your AI agent will reproduce.### 2. No-code helpers and light automationOnce you know the basics, you can start reducing repetitive column selection without writing code.1) Named ranges in Google SheetsInstead of repeatedly selecting the same block of columns, define a named range.- Select the columns you care about (for example, B:D).- Go to Data > Named ranges.- Give it a descriptive name, such as `crm_metrics`.- Later, access this range in formulas without manually selecting columns.Official docs: https://support.google.com/docs/2) Filter views and custom viewsIf you are constantly showing or hiding the same sets of columns for different stakeholders:- In Google Sheets, use Data > Filter views. Create a filter view that shows only the columns needed for sales, another for finance, and so on.- In Excel, convert your data range to a Table and use filters and custom views.This does not change how columns are selected under the hood, but it saves you from manually toggling visibility every time.3) Macros in Google SheetsMacros are a no-code way to record a series of actions – including column selections – and replay them.- In Google Sheets, go to Extensions > Macros > Record macro.- Perform your actions: select certain columns, apply formatting, insert formulas.- Stop recording and save.From now on, one macro click replays all those column selections and edits. Docs: https://support.google.com/docs/4) Macros in ExcelExcel’s macro recorder offers similar power.- Enable the Developer tab (via Options > Customize Ribbon if needed).- Click Record Macro.- Select the columns you need, run your formatting, insert formulas.- Stop recording.Run the macro later to reproduce the entire multi-column operation.These no-code tools move you from repetitive clicking to reusable actions. But they are still bound to a single application and usually one workbook at a time.### 3. Scaling with AI agents that use your computerNow imagine you are a CMO or agency owner. Every Monday, you or your team:- Open 5 Google Sheets reports and 3 Excel workbooks.- Select different sets of columns in each.- Clean, format, and copy those columns into client-ready dashboards.It is predictable, boring, and error-prone – which makes it perfect for an AI computer agent.Here is how an AI agent platform like Simular Pro can handle multi-column selection at scale.1) Cross-app reporting sweepsWorkflow:- The agent opens a specified Google Sheet.- It uses the same gestures you would: clicks column letters, uses Shift and Ctrl/Cmd equivalents, and applies filters or formats.- Then it switches to Excel, opens a workbook, selects matching columns, and aligns them for export.Pros:- Works across desktop, browser, and cloud apps in a single run.- Production-grade reliability: thousands of steps are logged and replayable.- Every click is transparent and inspectable; you can see exactly which columns were selected.Cons:- Requires initial setup and clear instructions for each report pattern.- Overkill for a one-off, tiny change.2) Automated client report assemblyFor agencies and sales teams:- You define the ideal report layout: which columns from which Sheets and Excel files matter for each client.- The Simular agent is instructed to open those files, select the right columns, and paste or write them into a master dashboard.- It can even combine this with web tasks – for example, pulling stats from a CRM or ad platform into the correct columns.Pros:- Dramatically cuts report preparation time.- Reduces risk of misaligned columns or missed data.- Easy to scale from 5 to 50 clients because the agent repeats the same column logic.Cons:- Needs occasional maintenance when column structures change.3) Data validation and cleanup passesMulti-column selection is also critical when cleaning or validating data.- The agent selects columns that feed key formulas (like VLOOKUP or ARRAYFORMULA setups seen in Stack Overflow examples).- It checks for empty cells, type mismatches, or outliers.- It can auto-fix simple issues or flag rows back to a human reviewer.Pros:- Turns tedious column-by-column checks into an overnight agent run.- Pairs well with Simular’s transparent execution: you audit what changed, step by step.Cons:- Requires thoughtful rules so the agent does not over-correct.By combining strong manual habits, no-code shortcuts, and AI agents that literally operate Google Sheets and Excel for you, column selection stops being a bottleneck. It becomes just another repeatable step in a larger, reliable workflow that your AI can execute while you focus on strategy, clients, and revenue.
Sometimes you do not just want a block of columns; you want every second one, such as dates in B, D, F and so on. Google Sheets does not have a native pattern-select feature, but you can get there fast with a mix of tricks.On desktop:1) Click the first target column header, for example B.2) Hold Ctrl (Windows/ChromeOS) or Cmd (Mac).3) While holding, click D, F, H and any other alternate columns you need.4) Release – all selected columns will now highlight together.If you need this pattern regularly, save time by using named ranges or macros:- First, perform the Ctrl/Cmd-click selection once.- In Sheets, go to Data > Named ranges and name it something like `every_second_column`.- Next time, reference that range in formulas instead of manually selecting columns.For more on multi-column operations and shortcuts, check the Google Sheets Help Center: https://support.google.com/docs/In Excel, the same Ctrl/Cmd-click approach works on column headers, and you can also record a macro while performing the pattern selection and reuse it.
To select non-adjacent columns in Google Sheets on desktop:1) Click the first column header you want (for example, B).2) Hold Ctrl on Windows/ChromeOS or Cmd on Mac.3) While holding, click additional column headers such as E, H, or K.4) Release the key – all of those columns should remain highlighted.If this does not work on a Mac, a common cause (reported in Apple Community threads) is a browser extension intercepting the Cmd-click. Troubleshoot by:- Opening Sheets in an incognito or private window.- Disabling extensions one by one until Cmd-click works again.On mobile, Sheets does not fully support non-adjacent column selection. You can tap a header and drag handles to extend a continuous range, but you cannot easily skip columns. For complex selection work, switch to desktop.Refer to Google Docs Editors Help for device-specific behaviors: https://support.google.com/docs/ and search for keyboard shortcuts and selection tips.
If Ctrl or Cmd click is not letting you select multiple columns in Google Sheets, work through these checks:1) Are you clicking column headers?Multi-select only works when you click the letters at the top (A, B, C). Ctrl/Cmd-clicking cells inside the grid will not select entire columns.2) Are you holding the key the whole time?You must keep Ctrl (Windows/ChromeOS) or Cmd (Mac) pressed while clicking each additional header. If you release the key too early, the prior selection is cleared.3) Browser extensions and pluginsOn Mac especially, some browser extensions interfere with command-click behavior. As reported in Apple’s support forums, opening Sheets in an incognito window often restores normal selection. If so, disable extensions one at a time until you find the culprit.4) Try another browser or profileTest in a different browser (for example, Chrome vs Safari) or a clean profile. If it works there, you know the issue is environmental, not Sheets itself.If problems persist, consult the Google Docs Editors Help Center at https://support.google.com/docs/ and search for keyboard shortcuts or selection issues.
On mobile, selection is more limited than on desktop, but you can still work efficiently with a few gestures.In Google Sheets mobile app:1) Tap a column letter to select the entire column.2) To expand to adjacent columns, drag the blue selection handles left or right. This lets you span several neighboring columns.3) Use the toolbar to format, hide, or clear those columns.Non-adjacent column selection (for example, B and E but not C or D) is not supported in the same way as desktop Ctrl/Cmd-click. For those patterns, switch to a laptop or desktop browser.In Excel mobile:1) Tap the column letter to select a full column.2) Drag the handles to cover adjacent columns.3) Use the bottom ribbon for formatting or inserting.When mobile limitations slow you down, a practical pattern is to let an AI agent operate on your desktop: you keep working on strategic review from your phone while the agent remote-controls Sheets or Excel on a machine with full keyboard and mouse precision.
AI agents shine whenever a task is repetitive, precise, and cross-application – which describes multi-column work perfectly.Here is how a Simular-style AI computer agent can help:1) You define the workflow once:- Open a specific Google Sheet or Excel file.- Select defined columns (for example, A:C for IDs, F:H for campaign metrics).- Apply consistent formatting, filters, or formulas.- Export or copy the results to a client-facing document.2) The agent learns by imitationUsing a platform like Simular Pro, you effectively show the agent what to click and in what order. Because every action is transparent and logged, you can review: Did it select the right columns? Did it skip anything?3) You scale it across accountsOnce the pattern is proven, the same agent can repeat it for every client sheet or regional workbook: open file, select the right columns, update, save, and close – thousands of safe, deterministic steps.This not only saves hours of manual selection but also reduces human error, letting business owners, agencies, and marketers focus on analysis and decisions rather than on remembering keyboard shortcuts.